Costel Chirila, PhD

Director, Biostatistics

Practice Area
Office Location
Telecommuter - USA

PhD, Statistics
MS, Statistics
University of Kentucky, Lexington, KY

BA, Economics
BS, Mathematics
Al. I. Cuza University, Iasi, Romania

Costel Chirila, PhD, is a Director of Biostatistics in RTI-HS with more than 10 years of experience as a biostatistician in the pharmaceutical industry. Dr. Chirila worked for several years as a statistician with pharmaceutical companies designing and analyzing clinical trials (including phase 1), providing biostatistical support for the discovery and development of diagnostic products (biomarker identification), and writing statistical analysis plans and statistical reports. In his role at RTI-HS, he manages various projects in which he plans, implements, and interprets the analysis of a variety of studies, including health economics (within-trial health care resource use and cost-effectiveness), epidemiology (burden of illness, risk evaluation, treatment patterns, and mitigation strategy), meta-analyses (direct, indirect, and mixed treatment comparisons), patient-reported outcomes (quality-of-life, mapping health-state utility scores), and phase 1 clinical trial analyses. Dr. Chirila has experience with various statistical methods, including generalized linear mixed modeling, survival-analysis, nonparametric modeling, receiver operating characteristic curves, statistical (i.e., machine) learning including variable and model selection using resampling techniques (e.g., cross-validation, bootstrapping). He also has programming experience with SAS and R/S-Plus. He has worked cross-functionally and has exposure to numerous disease areas, including amyotrophic lateral sclerosis, asthma, diabetes, insomnia, schizophrenia, plaque psoriasis, and various oncology areas (i.e., prostate cancer, colorectal cancer, breast cancer, myelofibrosis).

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