Rowen D, Labeit A, Stevens K, Elliott J, Mulhern B, Carlton J, Basarir H, Brazier J. Estimating a preference-based single index measuring the quality-of-life impact of self-management for diabetes. Med Decis Making. 2018 Jun 1. doi: 10.1177/0272989X18784291.


OBJECTIVE: Self-management is becoming increasingly important in diabetes but is neglected in conventional preference-based measures. The objective of this paper was to generate health state utility values for a novel classification system measuring the quality-of-life impact of self-management for diabetes, which can be used to generate quality-adjusted life years (QALYs).

METHODS: A large online survey was conducted using a discrete choice experiment (DCE), with duration as an additional attribute, on members of the UK general population ( n = 1,493) to elicit values for health (social limitations, mood, vitality, hypoglycaemia) and non-health (stress, hassle, control, support) aspects of self-management in diabetes. The data were modelled using a conditional fixed-effects logit model and utility estimates were anchored on the one to zero (full health to dead) scale.

RESULTS: The model produced significant and consistent coefficients, with one logical inconsistency and 3 insignificant coefficients for the milder levels of some attributes. The anchored utilities ranged from 1 for the best state to -0.029 for the worst state (meaning worse than dead) defined by the classification system.

CONCLUSION: The results presented here can potentially be used to generate utility values capturing the day to day impact of interventions in diabetes on both health and self-management. These utility values can potentially be used to generate QALYs for economic models of the cost-effectiveness of interventions in diabetes.

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