Davis KL, Mitra D, Yen L. Clinical characteristics, treatment patterns, and resource utilization in a real-world European population with diverticulitis. Poster presented at the 2012 ISPOR 15th Annual European Congress; November 9, 2012. Berlin, Germany. [abstract] Value Health. 2012 Nov; 15(7):A535-6.

OBJECTIVES: We documented the clinical characteristics, treatment patterns, and resource utilization associated with diverticulitis in a real-world European population.

METHODS: Data were abstracted from medical charts of 1,509 patients in 5 countries (~300 per country): United Kingdom, Germany, France, Netherlands, and Spain. Inclusion criteria were: diagnosed with diverticulitis during Jnuary 1, 2007–September 30, 2010; aged =18 years at first (index) diagnosis; no history of colon cancer; not enrolled in diverticulitis-related clinical trial; and =12 months of chart history after index diagnosis. Study measures were evaluated over all available post-index follow-up (=12 months).

RESULTS: Mean [SD] age at index was 61.7 [11.2] years and 55% of patients were male. Diagnosis setting was evenly distributed by general practitioner (29%), specialist (24%), emergency (24%), and hospital (22%). Diabetes was the most common chronic comorbidity (23% of patients) and 20% of patients were considered obese. More than half of patients presented with or subsequently developed diverticulitis-related complications, most commonly fissure/abscess/fistula (23%) or lower gastrointestinal (GI) hemorrhage (14%). Peritonitis, a life-threatening infection, was seen in 8.4% of patients. One-fifth (~20%) of patients did not receive antibiotics or other pharmacotherapies (i.e., aminosalicylates, analgesics, other GI drugs) used to manage diverticulitis and its symptoms. Among patients managed by office-based physicians (n=753), oral antibiotics and aminosalicylates (72% and 68% of patients, respectively) were the common treatments. Among those managed by hospital-based physicians (n=756), aminosalicylates were infrequently prescribed (11% of patients) and intravenous antibiotics were preferred over oral (67% and 36%, respectively). Fifty-seven percent of patients were hospitalized, with the majority being for acute disease management or diagnostics. Among those hospitalized, mean [SD] length of stay was 12.6 [31.8] days.

CONCLUSIONS: Diverticulitis presents a significant disease burden to health care systems and patients in Europe. Many patients with diverticulitis present with or develop serious complications, leading to frequent hospitalization and long hospital stays.

Share on: