Herring W, Ciarametaro M, Mauskopf J, Wamble D, Sils B, Dubois R. What might have happened: the impact of interrupting entry of innovative drugs on disease outcomes in the United States. Expert Rev Pharmacoecon Outcomes Res. 2022 Jun;22(4):529-41. doi: 10.1080/14737167.2022.2035219

INTRODUCTION: This study estimated the extent to which drug innovations over the past 30 years may have improved outcomes for six diseases.

AREAS COVERED: We analyzed six diseases (ischemic heart disease, lung cancer, breast cancer, human immunodeficiency virus [HIV] infection, type 2 diabetes mellitus, and rheumatoid arthritis [RA]) with significant mortality or morbidity for which there have been major drug innovations over the past 30 years. We used US data from the Global Burden of Disease (GBD) database and a patient registry to perform counterfactual time series analyses predicting the improved health outcomes that may have been associated with major drug innovations. For 5 conditions using data from the GBD study, years of life lost per individual with the condition could have been higher by 17.1% (breast cancer) to 660.6% (HIV infection) in 2017 had the major drug innovations not been introduced. For RA, using patient registry data, patients' functional status could have been 11.5% worse had biological therapies not been introduced.

EXPERT OPINION: Over the next 5 years, policies targeting drug prices should be broadened to include all health care services. In addition, the value of the pharmaceutical industry for generating rapid responses to new diseases should be recognized.

Share on: