McLeod L. Review of the Task Force Report on PRO data collection in clinical trials using mixed modes. Value Health. 2014 Jul;17(5):491-2. doi: 10.1016/j.jval.2014.06.003.


Congratulations to the ISPOR PRO Mixed Modes Good Research Practices Task Force [1] for tackling a challenging question that many patient-reported outcome (PRO) researchers have pondered either publicly or privately as they review PRO results tables based on data collected through a combination of data collection methods: “Would these results and the study conclusions be different if the same mode had been employed?” The report’s general recommendation to “Just say no!” to mixing modes within a single study (or set of studies that may be pooled) is good advice and, if followed, will save many headaches and resources.

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