Poulos C, Marcek T, Chintakayala P, Boeri M, Francis A, Langevin E, Petigara T, O'Connor J, Samant S. Preferences of nurses in the United Kingdom for attributes of pediatric hexavalent vaccines: a discrete-choice experiment. Expert Rev Pharmacoecon Outcomes Res. 2025 Apr;25(4):543-50. doi: 10.1080/14737167.2025.2450352


BACKGROUND: We evaluated UK nurses’ preferences for pediatric hexavalent vaccine attributes.

RESEARCH DESIGN AND METHODS: In a discrete-choice experiment study, 150 nurses chose between 2 hypothetical pediatric hexavalent vaccines with varying attribute levels (device type, plastic in packaging, time on the market, and time the vaccine can stay safely at room temperature) in a series of choice questions. Using random-parameters logit-model estimates, conditional relative attribute importance (CRAI) and odds ratios (ORs) were calculated.

RESULTS: Device type (with associated preparation time and risk of dosage errors) was the most important attribute (CRAI: 61%), followed by years on the market (CRAI: 25%). The odds of choosing a prefilled syringe were nearly 3 times the odds of choosing syringe-and-vial combinations requiring reconstitution (OR, 2.80; 95% confidence interval [CI], 1.93-3.68). Vaccines on the market for <1 year were less likely to be preferred to vaccines available for >3 years (OR, 0.66; 95% CI, 0.47-0.84). ORs for time a vaccine can stay at room temperature (3 vs. 6 days) (0.94; 95% CI, 0.71-1.16) and plastic blisters in packaging (1.19; 95% CI, 0.80-1.56) were not significant, indicating that these attributes did not influence choices.

CONCLUSIONS: In this survey, nurses’ preferences were mainly influenced by device type.

Share on: