Wall ME, Taylor H, Ambrosio L, Davis K. Plant Antitumor Agents. III. A Convenient Separation of Tannins from Other Plant Constituents. J Pharm Sci. 1969 Jan 1;58:839.

Several methods were tested for the nondestructive separation of tannins from other plant constituents which might have antitumor activity. A comparison was made of precipitation of tannins by caffeine or lead acetate and chromatography on polyamide. The caffeine procedure was preferred over lead acetate; both tannins and nontannins were effectively separated and the caffeine conveniently removed. Polyamide was an effective tannin remover; nontannins were easily collected but tannins were irreversibly adsorbed. The application of the caffeine procedure to a variety of plants is described.

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