Calhoun S, Kutikova L, Hollis KA, Helme K, Miller A, Schwarz TF. A novel approach to capturing real-world reasons behind use and satisfaction of NVX-CoV2373 booster use among German adults: direct-to-patient enrollment. Poster presented at the ISPOR Europe 2023; November 14, 2023. Copenhagen, Denmark. [abstract] Value Health. 2023 Dec; 26(12 Supplement):S490. doi: 10.1016/j.jval.2023.09.2649

OBJECTIVES: As COVID-19 transitions from a global public health emergency to an endemic disease, individuals at increased risk of severe COVID-19 need continued protection due to the constant presence of the SARS-CoV-2 virus. The German Standing Committee on Vaccination (STIKO) recommends all authorized vaccines including NVX-CoV2373, the Novavax COVID-19 vaccine, as a primary series and booster dose. STIKO recommends an annual booster dose for the following high-risk groups: adults > 60 years, adults with chronic medical conditions, persons being cared for in nursing homes, and healthcare workers. To date, there are no real-world data in Germany describing the use of, reactogenicity, and satisfaction with NVX-CoV2373 boosters, particularly as infrequent use of NVX-CoV2373 makes recruitment for real-world studies challenging.

METHODS: To overcome challenges with traditional recruitment, the study will implement a novel direct-to-patient enrollment approach through online technology using study-specific algorithms that evaluate web traffic across more than 1,500 websites, social media platforms, mobile applications, and patient advocacy groups. If an individual’s online activity aligns with the algorithm, a study advertisement will appear, allowing the individual to indicate interest. Interested individuals will receive an email detailing the study design and a link to electronically consent and answer eligibility questions. After consenting, patients will participate in a video conference to provide proof of their NVX-CoV2373 booster and enroll in the study. Participants will then complete a survey to assess their perceptions of motivators of vaccine choice, impact on daily activities, reactogenicity, and overall satisfaction with the vaccine.

RESULTS: Data collection will begin in fall 2023. This cross-sectional study will enroll adults residing in Germany who received an NVX-CoV2373 booster within 30 days of enrollment.

CONCLUSIONS: Study will descriptively characterize users and describe reasons for receiving the NVX-CoV2373 booster and evaluate reactogenicity and any impact on daily activities following the booster dose.

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