Layton JB, McGrath LJ, Sahrmann JM, Ma Y, Dharnidharka VR, O’Neil C, Weber DJ, Butler AM. Comparative safety of high-dose versus standard-dose influenza vaccination in patients with end-stage renal disease. Vaccine. 2020 Jun 6;38(33):5178-86.

BACKGROUND: High-dose influenza vaccine (HDV) is an alternative vaccination strategy in patients with end-stage renal disease (ESRD), though the safety of HDV has not been evaluated in this population. The objective of this study was to estimate the relative occurrence of adverse vaccine reactions in patients with ESRD following vaccination with HDV compared with standard-dose influenza vaccine (SDV).

METHODS: Using data from the United States Renal Data System, we identified patients with ESRD aged ≥65 years at influenza vaccination during yearly influenza seasons from 2010 through 2016. Patients were followed after vaccination to observe serious (anaphylaxis, angioedema, seizure, encephalopathy, Guillain-Barré syndrome [GBS], and short-term mortality) and milder (urticaria/hives, rash, pain in limb, cellulitis, myalgia/myositis, fever, nausea and vomiting, diarrhea, and syncope) adverse events. Propensity score-weighted hazard ratios (HRs) and 95% confidence intervals (CIs) for HDV versus SDV were estimated with Cox proportional hazards models.

Of 520,876 vaccinations observed (mean age=74.7 years at vaccination; 63% white race), 7.4% were HDV. For the serious events, the weighted HRs were null for seizure, encephalopathy, and mortality and inestimable due to too few cases for anaphylaxis, angioedema, and GBS. For milder vaccine reactions, the weighted HRs demonstrated generally increased risks in the HDV group, including rash (HR=1.86; 95% CI, 1.34-2.57), diarrhea (HR=1.26; 95% CI, 1.07-1.50), pain in limb (HR=1.23; 95% CI, 1.12-1.34), and myalgia/myositis (HR=1.16; 95% CI, 1.04-1.30).

CONCLUSIONS: While the risks of serious adverse events were low and similar between treatment groups, HDV recipients had increased risks of several milder adverse events compared with SDV recipients, consistent with clinical trial findings in the general population of older adults. The risk-benefit tradeoff of HDV versus SDV use in patients with ESRD should be carefully considered given these safety results and the high comorbidity burden in this population.

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