Stull DE, Wasiak R, Kreif N, Raluy M, Colligs A, Seitz C, Gerlinger C. Validation of the SF-36 in patients with endometriosis. Qual Life Res. 2014 Feb;23(1):103-17.

OBJECTIVES: Endometriosis presents with significant pain as the most common symptom. Generic health measures can allow comparisons across diseases or populations. However, the Medical Outcomes Study Short Form 36 (SF-36) has not been validated for this disease. The goal of this study was to validate the SF-36 (version 2) for endometriosis.

METHODS: Using data from two clinical trials (N = 252 and 198) of treatment for endometriosis, a full complement of psychometric analyses was performed. Additional instruments included a pain visual analog scale (VAS); a physician-completed questionnaire based on patient interview (modified Biberoglu and Behrman-B&B); clinical global impression of change (CGI-C); and patient satisfaction with treatment.

RESULTS: Bodily pain (BP) and the Physical Component Summary Score (PCS) were correlated with the pain VAS at baseline and over time and the B&B at baseline and end of study. In addition, those who had the greatest change in BP and PCS also reported the greatest change on CGI-C and patient satisfaction with treatment. Other subscales showed smaller, but significant, correlations with change in the pain VAS, CGI-C, and patient satisfaction with treatment.

CONCLUSIONS: The SF-36-particularly BP and the PCS-appears to be a valid and responsive measure for endometriosis and its treatment.

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