Stull DE, Vernon MK, Canonica GW, Crespi S, Sandor D. Using the congestion quantifier seven-item test to assess change in patient symptoms and their impact. Allergy Asthma Proc. 2008 May;29(3):295-303. doi: 10.2500/aap.2008.29.3119.

Generally, nasalcongestionis reported to be the most troublesome symptom of allergic rhinitis and has been shown to have negative effects on sleep, productivity, work, and school performance. A newpatient-reported outcome (PRO) tool called theCongestionQuantifierSeven-ItemTest(CQ7) was developed and shown to be a reliable and valid screening tool for nasalcongestion. The purpose of this study was toassessthe CQ7 as a tool for clinical use that can monitor changes in nasalcongestionor determine if patients are showing meaningful improvement insymptoms. This study examined the responsiveness of the CQ7 to changes in nasalcongestionand changes in relevant PRO to explore whether the CQ7 can serve as a monitoring tool and a valid screening tool for nasalcongestionusing latent growth curve models. Results showed that the CQ7 is sensitive to changes in patients'symptomsand theirimpact.Changein the CQ7 from baseline to day 15 was highly related to thechangein symptom scores from baseline to day 15 (beta = -0.99); and regression coefficients for the relationships between the CQ7 and changes in the other PRO subscales also were very high (betas ranged from -0.79 to -0.95), lending evidence to support the use of the CQ7 as a monitoring tool. The large sizes of the coefficients suggest that the efficient,seven-itemmonitoring tool captureschangeincongestionvery well. Analyses of responsiveness tochangesuggest that a three- to four-point improvement is meaningful to patients.

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