Snow ND, Mangel AW, Sharara AI, Liddle RA. Potassium channels regulate cholecystokinin secretion in STC-1 cells. Biochem Biophys Res Commun. 1993 Sep 30;195(3):1379-85.

Following blockade of plasma membranepotassiumchannelswith barium or tetraethylammonium chloride, release ofcholecystokininwas increased in an intestinal cell line (STC-1). Treatment with calcium channel blockers inhibited barium- or TEA-inducedsecretion. Barium chloride also stimulated 45Ca efflux fromSTC-1cells. Whole cell patch clamp recordings revealed a voltage-activated, L-type calcium current. We conclude that, inhibition of basally activepotassiumchannelsmay depolarizeSTC-1cells, producing activation of voltage-gated calcium influx pathways. Influx of calcium may lead to a release of intracellular calcium which stimulatescholecystokininsecretion.

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