Lim SY, Lima JAC, Zhao D, Rampal S, Zhang Y, Cho J, Pastor-Barriuso R, Cainzos-Achirica M, Bello S, Choi Y, Chang Y, Ryu S, Shin H, Lim S, Guallar E. Lung function and arterial stiffness in apparently healthy men and women: the Kangbuk Samsung health study. Poster presented at the American Heart Association – American Stroke Association EPI-Lifestyle 2015; March 2015. Baltimore, MD. [abstract] Circulation. 2015 Mar 10; 131(Suppl 1).

INTRODUCTION: The association between lung function and arterial stiffness in young and middle-aged asymptomatic adults is uncertain.

HYPOTHESIS: We assessed the hypothesis that declining lung function is associated with increasing and arterial stiffness in a large sample of young and middle-age asymptomatic men and women.

METHODS: Cross-sectional study of 95,705 men and women without a history of cardiovascular disease, obstructive lung disease, or cancer who underwent a health screening examination during 2006 - 2012. Prediction equations were used to estimate the percentage of predicted forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) from age-, height-, and weight-adjusted population norms. Pulse wave velocity (PWV) was obtained from bilateral brachial and posterior tibial artery pressure waveforms recorded using the oscillometric method.

The mean age of study participants was 42.7 years in men and 40.7 years in women; 63.9% of study participants were men. In multivariable adjusted linear regression models, PWV ratios comparing men with FVC less than 60 %predicted to those with FVC greater than or equal to 100 %predicted were 1.08 (95% confidence interval 1.06 to 1.09), 1.08 (1.05 to 1.11), 1.07 (1.04 to 1.09), and 1.09 (1.06 to 1.11) among all, never, former, and current smoking men, respectively. The corresponding PWV ratios in women were 1.02 (1.00 to 1.03), 1.02 (1.00 to 1.03), 0.98 (0.91 to 1.06), and 1.06 (0.94 to 1.19). Similar results were observed for FEV1 in men and women. In spline regression models, adjusted PWV ratios increased with decreasing levels of FVC and FEV1 in both men and women (Figure).

CONCLUSIONS: Declining lung function was associated with increased arterial stiffness in apparently healthy young and middle aged men and women, regardless of smoking exposure. This association was observed in asymptomatic participants with preserved lung function. Lung function may thus be an important determinant of arterial stiffness and vascular aging later in life.

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