Kaye JA, Jick H. Antibiotics and the risk of breast cancer. Epidemiology. 2005 Sep;16(5):688-90.

BACKGROUND:Two recent studies found a positive association between antibiotic use and therisk ofbreast cancer.METHODS:Using information from the U.K. General Practice Research Database, we identified 1268 cases of incidentbreast cancer(40- to 79-year-old women diagnosed in 1987 to 2002 who had at least 6 years of history recorded in the General Practice Research Database) and 6291 female controls matched to the cases on age, general practice, and duration of history recorded in the General Practice Research Database. We ascertained antibiotic prescriptions (penicillins, cephalosporins, sulfonamides, macrolides, tetracyclines, quinolones, metronidazole, and nitrofurantoin) recorded up to 1 year before the index date.RESULTS:Odds ratios (95% confidence intervals) ofbreast cancerfor 0, 1-50, 51-100, 101-500, and 501 or more cumulative days of antibiotic use were 1.0 (reference), 1.0 (0.9-1.2), 0.9 (0.7-1.2), 0.9 (0.7-1.3), and 1.2 (0.6-2.4).CONCLUSIONS:These data do not support the hypothesis that antibiotic use is associated with an increasedrisk ofbreast cancer.

Share on: