Rosenzweig J, McSorley D. Adaptive clinical trial design. 2016. Research Triangle Park: RTI Health Solutions.

Clinical trials in the pharmaceutical industry are incorporating adaptive design methods with greater frequency, as the economic resources needed for clinical research have expanded. These designs leverage accumulating information during a trial in real time and have the potential to reduce the costs and streamline the time frames for clinical trials in drug development, particularly in the earlier phases during proof of concept and dose selection.

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