GEMCAD Symposium: Updates in the Multidisciplinary Treatment of Digestive Tumors

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April 4 to April 5, 2019
Hotel NH Eurobuilding
Madrid
Spain

Two RTI Health Solutions researchers provided methods presentations at the 2019 Symposium on Updates in Digestive Tumors sponsored by the Spanish Multidisciplinary Research Group on Digestive Cancers. Their presentations centered on how to analyze and interpret randomized clinical trials: intention-to-treat vs. per-protocol analysis.

The intention-to-treat (ITT) comparison is the primary, if not the only, analytic approach of many randomized clinical trials (RCTs). ITT requires that patients assigned to each treatment arm are kept in that arm during the analysis even if they do not receive the assigned treatment. The first part of the session focused on the strengths of the ITT and the reasons why ITT is currently the preferred analysis for RCTs. ITT weaknesses were also reviewed. The second part of the session addressed issues that can arise from uncritical reliance on the ITT analysis in RCTs, outlined alternative analytic approaches (e.g., per-protocol analyses), and provided guidance on how to choose among them. Per-protocol analyses have improved in the last decades thanks to the development of g-methods, which Dr. Kaye and Dr. Xabier Garcia de Albeniz introduced. 

Pros of the intention-to-treat analysis. When and why not to use per-protocol analysis. 
Presenter: Dr. James Kaye
Thursday, 4th April
16:00 - 16:40h

How to analyze and interpret randomized clinical trials:  intention-to-treat vs. per-protocol analysis. 
Presenter: Dr. Xabier Garcia de Albeniz
Thursday, 4th April
16:40 - 17:20h

Dr. Xabier Garcia de Albeniz is a member of the organizing and scientific committees and will be chairing the Table I session. Dr. Kaye is a member of the scientific committee.

If you would like to reach out to either Dr. Kaye or Dr. Garcia de Albeniz, please click on their names above.

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