Allen Mangel, MD, PhD - Executive Vice President, RTI Health Solutions
Allen Mangel, MD, PhD, is a gastroenterologist and Executive Vice President of RTI HS. Following completion of his medical training, Dr. Mangel did his internship and residency in internal medicine at Duke University Medical Center and then completed his gastroenterology fellowship also at Duke. Following completion of his formal training, he remained on the faculty in the Department of Medicine, Division of Gastroenterology, at Duke for 2 years. Dr. Mangel also has a PhD from the University of Illinois, where his research focused on control of electrical and mechanical activity in gastrointestinal smooth muscle.
After Dr. Mangel left Duke, he joined the gastroenterology clinical research department at GlaxoWellcome, where he conducted numerous clinical trials and directed product development teams. After departing GlaxoWellcome, he became Vice President of Research and Development at Salix Pharmaceuticals. He joined RTI International in 2003 and currently serves as Executive Vice President of RTI HS.
Dr. Mangel has led or participated in numerous FDA interactions, advisory committee presentations, label negotiations, and new drug application submissions, and he has authored more than 100 publications.
Christopher R. Simmons, CPA - Vice President, Finance and Operations
Chris Simmons, CPA, is Vice President, Finance and Operations for RTI-HS. In this role, he heads the support functions, which include the business affairs, business development, contracts, editorial services, finance, and project and proposal groups.
Mr. Simmons has spent 25 years in financial and operational roles, with particular focus on early-stage, rapidly growing technology and biotech businesses. Mr. Simmons began his career at KPMG Peat Marwick and moved to other public accounting firms whose focus was more on early-stage businesses. Mr. Simmons then moved into corporate finance as controller for Mitsubishi Semiconductor America, Inc., a semiconductor manufacturer. Upon leaving Mitsubishi, Mr. Simmons served 4 years as corporate controller and then vice president of finance for a start-up biotech company, Cogent Neuroscience, Inc.
Just prior to joining RTI-HS, Mr Simmons consulted for several other early-stage biotech and high-tech businesses as leader of finance.
Dave Obringer, JD - Vice President, Contracting and Business Relationships
Dave Obringer leads the contracting and procurement group supporting RTI-HS. He conducts legal and business review of contractual documents and supports the review and implementation of strategic alliances and acquisitions. He also leads or participates in the research and evaluation of important legal and business issues relevant to RTI-HS and the creation and implementation of procedures, processes, and tools for managing those issues, working with outside counsel as appropriate.
Mr. Obringer played a key role in the procurement and implementation of a strategic enterprise financial, project, and client management system for RTI-HS. He did likewise for the procurement and implementation of a validated training management system for RTI-HS, negotiating with the vendor and overseeing the validation and implementation of the system. He also served as a member of the RTI-HS Business Management Team, formulating strategic and business plans for RTI-HS and overseeing implementation of those decisions
Prior to joining RTI-HS, Mr. Obringer served as the lead transactional attorney and counsel at RTI International. In that role, he provided advice and counsel on corporate-wide legal and regulatory matters, reviewed and approved contractual and legal documents for the research business units, and provided counsel to RTI International's administrative units. He has consulted with and managed outside counsel as needed; managed a large legal/administrative team, including attorneys, contract professionals, and support staff; and served on the corporate steering committee overseeing the procurement and implementation of corporate-wide strategic financial systems.
Lawrence N. Bell, PhD - Vice President, Business Affairs
Lawrence Bell, PhD, is the Vice President of Business Affairs for RTI-HS. He has extensive management and hands-on experience consulting for and within the pharmaceutical industry to develop people, processes, and systems related to outcomes research, drug development, and health policy. At RTI-HS he has guided a number of business and technical functions, including Business Development, Office of Quality Assurance, Health Outcomes Strategy, and Health Economics. In addition, he has been extensively involved in the pre-IND (nonclinical) development of two novel chemical entities. He has broad experience with development strategy, including bench and scale-up chemistry, drug and dosage formulation and stability, and clinical trials.
For more than 25 years, he served as a management team member for various divisions and departments of a major pharmaceutical company, establishing and shaping the direction of a number of groups, including Project Planning (tasks and their dependencies, timelines, and costs/budgets to submit INDs and NDAs), Health Economics, Health Policy Research, Clinical Data Processing and Management, and Quality Assurance.
He has published in journals, including PharmacoEconomics, Journal of Medicinal Chemistry, International Journal of Technology Assessment in Health Care, Pharmacotherapy, Epilepsia, Journal of the American Chemical Society, and Journal of Organic Chemistry. Additionally, Dr. Bell was coauthor, coordinator, and editor for Chapter 3, “Estimating Drug Development Costs,” in the report “The Economics of TB Drug Development.”